Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myctm1(Nmyc1)Fwa
Name:	myelocytomatosis oncogene; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:2178231
Synonyms:	c-mycneo
Gene:	Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance:	Myctm1(Nmyc1)Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:62573
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: The entire second exon, the coding portion of the third exon and the intervening intron were replaced with the analogous sequences from Nmyc1 gene. A loxP flanked neomycin selection cassette was also inserted in the second intron in reverse transcriptional orientation. (J:62573)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:	42 strains or lines available

Original:	J:62573 Malynn BA, et al., N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 1;14(11):1390-9
All:	1 reference(s)