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Lrp1tm1Her
Targeted Allele Detail
Summary
Symbol: Lrp1tm1Her
Name: low density lipoprotein receptor-related protein 1; targeted mutation 1, Joachim Herz
MGI ID: MGI:2178192
Synonyms: LRP -
Gene: Lrp1  Location: Chr10:127374030-127457017 bp, - strand  Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
Alliance: Lrp1tm1Her page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30077
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into the coding sequence of the gene, upstream of the sequences encoding the second of the four ligand binding domains. (J:30077)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp1 Mutation:  211 strains or lines available
References
Original:  J:30077 Herz J, et al., LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation [published erratum appears in Cell 1993 May 7;73(3):428]. Cell. 1992 Oct 30;71(3):411-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory