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Htr2ctm1Knk
Targeted Allele Detail
Summary
Symbol: Htr2ctm1Knk
Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, Kazuko Nishikura
MGI ID: MGI:3823041
Synonyms: 5-HT2CR-VGV
Gene: Htr2c  Location: ChrX:145745509-145980273 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband D-F4
Alliance: Htr2ctm1Knk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142503
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 5 was replaced with one in which 5 adenosines were converted to guanosines by nucleotide substitutions giving rise to I156V, N158G and I160V amino acid substitutions. A floxed neo cassette was inserted upstream of exon 5 for selection purposes. Mice only express the isoform carrying these substitutions. (J:142503)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr2c Mutation:  12 strains or lines available
References
Original:  J:142503 Kawahara Y, et al., Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci. 2008 Nov 26;28(48):12834-44
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory