Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp73tm1Mak
Name:	transformation related protein 73; targeted mutation 1, Tak Mak
MGI ID:	MGI:3822523
Synonyms:	TAp73-
Gene:	Trp73  Location: Chr4:154140706-154224332 bp, - strand  Genetic Position: Chr4, 83.79 cM
Alliance:	Trp73tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:142848
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a floxed neo cassette. The absence of protein expression of all four TAp73 isoforms was confirmed by western blot analysis on ovary extracts. The deltaNp73 isoforms are expressed. (J:142848)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

List all tumor models in MMHCdb carrying Trp73tm1Mak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Trp73 Mutation:	42 strains or lines available

Original:	J:142848 Tomasini R, et al., TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev. 2008 Oct 1;22(19):2677-91
All:	19 reference(s)