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Gt(ROSA)26Sortm1(Hesx1)Jpmb
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Hesx1)Jpmb
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Juan Pedro Martinez Barbera
MGI ID: MGI:3822482
Synonyms: R26Cond-Hesx1
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135132
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Hesx1)Jpmb expresses 1 gene
 
Mutation detailsThe Hesx1 coding sequence was cloned into a vector containing a floxed cassette with a PGK-Neo selection marker and a tpA transcriptional stop sequence. By homologous recombination, this construct was inserted into the Gt(ROSA)26Sor locus. The loxP site orientations were inverted to avoid translation interference due to the presence of an ATG within the loxP sites. Upon Cre-mediated excision of the selection cassette/stop sequence, Hesx1 is transcribed under control of the Gt(ROSA)26Sor promoter. (J:135132)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  745 strains or lines available
References
Original:  J:135132 Andoniadou CL, et al., Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory