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Hesx1tm1(cre)Jpmb
Targeted Allele Detail
Nomenclature
Symbol: Hesx1tm1(cre)Jpmb
Name: homeobox gene expressed in ES cells; targeted mutation 1, Juan Pedro Martinez Barbera
MGI ID: MGI:3822473
Synonyms: Hesx1Cre
Gene: Hesx1  Location: Chr14:26716375-26724286 bp, + strand  Genetic Position: Chr14, 16.09 cM, cytoband A3-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135132
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe coding region of the Hesx1 gene was replaced with sequence encoding Cre recombinase, a polyA sequence and an Frt-flanked PGK-Neo cassette, via homologous recombination. The targeting vector was electroporated into CCE ES cells. ES cells were injected into B6 blastocysts to generate mice. Subsequently, the Pgk-Neo cassette was excised by crossing mice to ACTB:FLPe transgenic animals and maintained on a C57BL/6J background. (J:135132)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hesx1     Summary of all recombinase alleles driven by Hesx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hesx1 Mutation:  11 strains or lines available
References
Original:  J:135132 Andoniadou CL, et al., Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory