Hesx1tm1(cre)Jpmb
Targeted Allele Detail
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Symbol: |
Hesx1tm1(cre)Jpmb |
Name: |
homeobox gene expressed in ES cells; targeted mutation 1, Juan Pedro Martinez Barbera |
MGI ID: |
MGI:3822473 |
Synonyms: |
Hesx1Cre |
Gene: |
Hesx1 Location: Chr14:26716375-26724286 bp, + strand Genetic Position: Chr14, 16.09 cM, cytoband A3-B
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Alliance: |
Hesx1tm1(cre)Jpmb page
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Germline Transmission: |
Earliest citation of germline transmission:
J:135132
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Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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Strain of Origin: |
129S/SvEv-Gpi1c
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Hesx1tm1(cre)Jpmb expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Hesx1 (MGI:96071) |
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Mutation details: The coding region of the Hesx1 gene was replaced with sequence encoding Cre recombinase, a polyA sequence and an Frt-flanked PGK-Neo cassette, via homologous recombination. The targeting vector was electroporated into CCE ES cells. ES cells were injected into B6 blastocysts to generate mice. Subsequently, the Pgk-Neo cassette was excised by crossing mice to ACTB:FLPe transgenic animals and maintained on a C57BL/6J background.
(J:135132)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Hesx1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hesx1 Mutation: |
14 strains or lines available
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Original: |
J:135132 Andoniadou CL, et al., Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508 |
All: |
16 reference(s) |
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