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Hesx1tm1(cre)Jpmb
Targeted Allele Detail
Summary
Symbol: Hesx1tm1(cre)Jpmb
Name: homeobox gene expressed in ES cells; targeted mutation 1, Juan Pedro Martinez Barbera
MGI ID: MGI:3822473
Synonyms: Hesx1Cre
Gene: Hesx1  Location: Chr14:26716375-26724286 bp, + strand  Genetic Position: Chr14, 16.09 cM, cytoband A3-B
Alliance: Hesx1tm1(cre)Jpmb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135132
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Hesx1tm1(cre)Jpmb expression driven by 1 gene
 
Mutation detailsThe coding region of the Hesx1 gene was replaced with sequence encoding Cre recombinase, a polyA sequence and an Frt-flanked PGK-Neo cassette, via homologous recombination. The targeting vector was electroporated into CCE ES cells. ES cells were injected into B6 blastocysts to generate mice. Subsequently, the Pgk-Neo cassette was excised by crossing mice to ACTB:FLPe transgenic animals and maintained on a C57BL/6J background. (J:135132)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hesx1 (mouse)
Summary of all recombinase alleles driven by Hesx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Hesx1tm1(cre)Jpmb
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hesx1 Mutation:  14 strains or lines available
References
Original:  J:135132 Andoniadou CL, et al., Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory