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Gt(ROSA)26Sortm1(MYC/ERT2)Gev
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(MYC/ERT2)Gev
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Gerard Evan
MGI ID: MGI:3821930
Synonyms: R26lsl-MER
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(MYC/ERT2)Gev page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142030
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA fused human MYC and ESR1 (ERT2) sequence, preceded by a floxed neo cassette with a triple polyadenylation sequence and followed by an IRES-EGFP, was inserted into the ROSA locus. Expression of the fusion product can only be achieved through cre mediated removal of the neo cassette along with its polyadenlylation sequences. (J:142030)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:142030 Murphy DJ, et al., Distinct thresholds govern Myc's biological output in vivo. Cancer Cell. 2008 Dec 9;14(6):447-57
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory