Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igf1tm2Arge
Name:	insulin-like growth factor 1; targeted mutation 2, Argiris Efstratiadis
MGI ID:	MGI:3821754
Synonyms:	Igf1flox
Gene:	Igf1  Location: Chr10:87694127-87772904 bp, + strand  Genetic Position: Chr10, 43.7 cM
Alliance:	Igf1tm2Arge page

Germline Transmission:	Earliest citation of germline transmission: J:142247
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Intragenic deletion   Mutation details: Using ES cells containing Igf1tm1Arge in which exon 4 was replaced with a neo cassette, exon three was replaced with a full-length cDNA of the gene preceded by a floxed puromycin resistance cassette and three polyadenylation sequences from SV40. The full-length cDNA is only expressed when the polyadenylation sites have been removed. (J:142247)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:	27 strains or lines available

Original:	J:142247 Stratikopoulos E, et al., The hormonal action of IGF1 in postnatal mouse growth. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83
All:	1 reference(s)