Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scn11atm1Mdba
Name:	sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Mark Baker
MGI ID:	MGI:3818305
Synonyms:	Nav1.9-
Gene:	Scn11a  Location: Chr9:119582829-119654522 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
Alliance:	Scn11atm1Mdba page

Germline Transmission:	Earliest citation of germline transmission: J:141209
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 and 5 were replaced with a neo cassette eliminating the domain 1, S4 voltage sensor. The replacement causes a frameshift and introduce STOP codons in exon 6. The absence of full-length transcript expression was confirmed by RT-PCR. (J:141209)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn11a Mutation:	86 strains or lines available

Original:	J:141209 Ostman JA, et al., GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol. 2008 Feb 15;586(4):1077-87
All:	10 reference(s)