Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mesp2tm12Ysa
Name:	mesoderm posterior 2; targeted mutation 12, Yukimo Saga
MGI ID:	MGI:3817238
Synonyms:	P2EmB1D
Gene:	Mesp2  Location: Chr7:79460475-79463179 bp, + strand  Genetic Position: Chr7, 45.18 cM
Alliance:	Mesp2tm12Ysa page

Germline Transmission:	Earliest citation of germline transmission: J:141112
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Modified regulatory region) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Two Tbx6 binding sites contained within the minimal pre-somitic mesoderm enhancer region upstream of exon 1 were replaced with ones containing mutations at site B and site D. A floxed neo cassette inserted upstream of the enhancer region was removed by germ line, cre mediated recombination. (J:141112)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mesp2 Mutation:	30 strains or lines available

Original:	J:141112 Yasuhiko Y, et al., Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2. Development. 2008 Nov;135(21):3511-9
All:	1 reference(s)