Cbfa2t3tm1.1Swh
Targeted Allele Detail
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Symbol: |
Cbfa2t3tm1.1Swh |
Name: |
CBFA2/RUNX1 translocation partner 3; targeted mutation 1.1, Scott W Hiebert |
MGI ID: |
MGI:3815201 |
Synonyms: |
Mtg16- |
Gene: |
Cbfa2t3 Location: Chr8:123351880-123425848 bp, - strand Genetic Position: Chr8, 71.93 cM, cytoband E1
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Alliance: |
Cbfa2t3tm1.1Swh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:140967
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Parent Cell Line: |
TL1/TL-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Cbfa2t3tm1Swh heterozygotes were crossed with transgenic cre mice resulting in excision of exon 8 from the germline. It was predicted to be a null allele because splicing from exon 7 to exon 9 introduces a stop codon and would trigger nonsense-mediated mRNA decay. Gene inactivation in homozygotes was confirmed by a lack of signal in immunoblot assays of splenocyte nuclear extracts.
(J:140967)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cbfa2t3 Mutation: |
34 strains or lines available
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Original: |
J:140967 Chyla BJ, et al., Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol. 2008 Oct;28(20):6234-47 |
All: |
13 reference(s) |
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