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Cbfa2t3tm1.1Swh
Targeted Allele Detail
Summary
Symbol: Cbfa2t3tm1.1Swh
Name: CBFA2/RUNX1 translocation partner 3; targeted mutation 1.1, Scott W Hiebert
MGI ID: MGI:3815201
Synonyms: Mtg16-
Gene: Cbfa2t3  Location: Chr8:123351880-123425848 bp, - strand  Genetic Position: Chr8, 71.93 cM, cytoband E1
Alliance: Cbfa2t3tm1.1Swh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140967
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCbfa2t3tm1Swh heterozygotes were crossed with transgenic cre mice resulting in excision of exon 8 from the germline. It was predicted to be a null allele because splicing from exon 7 to exon 9 introduces a stop codon and would trigger nonsense-mediated mRNA decay. Gene inactivation in homozygotes was confirmed by a lack of signal in immunoblot assays of splenocyte nuclear extracts. (J:140967)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cbfa2t3tm1.1Swh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cbfa2t3 Mutation:  34 strains or lines available
References
Original:  J:140967 Chyla BJ, et al., Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol. 2008 Oct;28(20):6234-47
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory