Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trpm7tm1.1Clph
Name:	transient receptor potential cation channel, subfamily M, member 7; targeted mutation 1.1, David E Clapham
MGI ID:	MGI:3814706
Gene:	Trpm7  Location: Chr2:126633485-126718150 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband F2
Alliance:	Trpm7tm1.1Clph page

Germline Transmission:	Earliest citation of germline transmission: J:140630
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre mediated recombination of Trpm7tm1Clph resulted in deletion of exon 17. Deletion of exon 17 removes the sequence preceding the first transmembrane domain and generates a frame shift mutation. (J:140630)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpm7 Mutation:	98 strains or lines available

Original:	J:140630 Jin J, et al., Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31;322(5902):756-60
All:	2 reference(s)