Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Trpm7tm1Clph Name: transient receptor potential cation channel, subfamily M, member 7; targeted mutation 1, David E Clapham MGI ID: MGI:3814705 Synonyms: Trpm7fl Gene: Trpm7  Location: Chr2:126633485-126718150 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband F2 Alliance: Trpm7tm1Clph page

Representative images of grossly deformed, nonviable Trpm7tm1Clph/Trpm7tm1Clph Tg(CAG-cre/Esr1*)5Amc/0 embryos at E9.5 and E10.5 Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:140630
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted around exon 17 and an frt-flanked neo cassette was inserted within the floxed locus. The neo cassette was removed by in vivo flp mediated recombination. (J:140630)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpm7 Mutation:	98 strains or lines available

Original:	J:140630 Jin J, et al., Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31;322(5902):756-60
All:	18 reference(s)