Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Alpltm1(cre)Nagy
Name:	alkaline phosphatase, liver/bone/kidney; targeted mutation 1, Andras Nagy
MGI ID:	MGI:2177588
Synonyms:	Alpl-cre, TNAPCre, TNAP-Cre, TNAP/Cre
Gene:	Alpl  Location: Chr4:137469044-137523695 bp, - strand  Genetic Position: Chr4, 70.02 cM
Alliance:	Alpltm1(cre)Nagy page

Germline Transmission:	Earliest citation of germline transmission: J:60934
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Alpltm1(cre)Nagy expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Alpl (MGI:87983)   Mutation details: An IRES-cre gene followed by a neomycin gene was inserted into exon 6 of the gene. This allele expresses Cre recombinase in primordial germ cells. (J:60934)

Activity:	Tissue activity of this recombinase allele
Driver:	Alpl (mouse) Summary of all recombinase alleles driven by Alpl. Comparative matrix view of recombinase activities Alliance mouse Alpl gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

27 assay results 2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Alpl Mutation:	351 strains or lines available

Original:	J:60934 Lomeli H, et al., Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis. 2000 Feb;26(2):116-7
All:	84 reference(s)