Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	FusGt(U3NeoSV1)HO14Ggh
Name:	fused in sarcoma; gene trap HO14, Geoffrey G Hicks
MGI ID:	MGI:2177561
Synonyms:	Fus -, TLS-
Gene:	Fus  Location: Chr7:127565276-127581204 bp, + strand  Genetic Position: Chr7, 69.87 cM
Alliance:	FusGt(U3NeoSV1)HO14Ggh page

Mutant Cell Line:	HO14
Germline Transmission:	Earliest citation of germline transmission: J:60213
Parent Cell Line:	D3H (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: U3NeoSV1   Mutation details: The mutation was generated by the random insertion of the gene trap vector U3NeoSV1 into exon 12 of the gene. RT-PCR and Northern blot analysis demonstrated that a truncated transcript is produced from this allele, and western blot analysis confirmed that low levels of a truncated protein were expressed from this allele. However, the expressed product is not expected to retain activity due to missing nucleic acid binding domains. (J:60213)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fus Mutation:	39 strains or lines available

Original:	J:60213 Hicks GG, et al., Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat Genet. 2000 Feb;24(2):175-9
All:	8 reference(s)