Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabra2tm1Dns
Name:	gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1, D N Stephens
MGI ID:	MGI:3812421
Gene:	Gabra2  Location: Chr5:71115735-71253192 bp, - strand  Genetic Position: Chr5, 37.59 cM
Alliance:	Gabra2tm1Dns page

Germline Transmission:	Earliest citation of germline transmission: J:140077
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was replaced with a floxed neo cassette. Germ line, cre mediated recombination was used to remove the neo cassette. (J:140077)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra2 Mutation:	34 strains or lines available

Original:	J:140077 Dixon CI, et al., Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. Pharmacol Biochem Behav. 2008 Jul;90(1):1-8
All:	3 reference(s)