Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nct1/Nct2tm1Nbh
Name:	non-coding in testis 1; targeted mutation 1, Norman B Hecht
MGI ID:	MGI:3811743
Synonyms:	Nct1/2, Nct1tm1Nbh
Gene:	Nct1  Location: Chr2:92378600-92379284 bp, + strand
Alliance:	Nct1/Nct2tm1Nbh page

Germline Transmission:	Earliest citation of germline transmission: J:139921
Parent Cell Line:	EC7.1 (ES Cell)
Strain of Origin:	(C57BL/6J x 129X1/SvJ)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: A loxP-flanked neomycin selection cassette replaced the entire coding sequence of the two gene loci. PicoRNAs (piRNA) from the gene loci were not detectable by real-time PCR on RNA from the testes of homozygous mice. Also, piRNAs up to 7 kb upstream (piR-135965) and 8 kb downstream of the deleted region (piR-111581) were markedly decreased in the testes of male homozygotes. Expression of the L1 retrotransposon, a target of some of these piRNAs, was increased in the testes of these mice. (J:139921)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nct1 Mutation:	0 strains or lines available

Original:	J:139921 Xu M, et al., Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control. Biol Reprod. 2008 Jul;79(1):51-7
All:	1 reference(s)