Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Admtm1.1Mtnz
Name:	adrenomedullin; targeted mutation 1.1, Alfredo Martinez
MGI ID:	MGI:3811634
Gene:	Adm  Location: Chr7:110226868-110229027 bp, + strand  Genetic Position: Chr7, 57.7 cM
Alliance:	Admtm1.1Mtnz page

Germline Transmission:	Earliest citation of germline transmission: J:138817
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The loxP sites were introduced into both 5' and 3' of 4 exons of the gene from Admtm1Mtnz was deleted by crossing with animals expressing cre under a ubiquitous promoter (unspecified) resulting in a null allele. Homozygous mice showed comlete lack of protein product from conception. (J:138817)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adm Mutation:	13 strains or lines available

Original:	J:138817 Fernandez AP, et al., Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12581-6
All:	1 reference(s)