Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Lrrk2tm1(KOMP)Mbp
Name:	leucine-rich repeat kinase 2; targeted mutation 1, Mouse Biology Program, UC Davis
MGI ID:	MGI:4950117
Gene:	Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance:	Lrrk2tm1(KOMP)Mbp page
IMPC:	Lrrk2 gene page

Mutant Cell Lines:	DEPD00555_3_A03, DEPD00555_3_A04, DEPD00555_3_C03, DEPD00555_3_C04, DEPD00555_3_D01, DEPD00555_3_E02, DEPD00555_3_E03, DEPD00555_3_F01, DEPD00555_3_F04, DEPD00555_3_H02, DEPD00555_3_H03
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3642 starting at position 91593461 and ending at position 91597103 of Chromosome 15 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Lrrk2 Mutation:	156 strains or lines available

Original:	J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:	2 reference(s)