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Abca3tm1a(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Abca3tm1a(EUCOMM)Hmgu
Name: ATP-binding cassette, sub-family A member 3; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4946768
Gene: Abca3  Location: Chr17:24570997-24629178 bp, + strand  Genetic Position: Chr17, 12.38 cM, cytoband A3.3
Alliance: Abca3tm1a(EUCOMM)Hmgu page
IMPC: Abca3 gene page
Mutation
origin
Mutant Cell Lines:  HEPD0715_9_A02, HEPD0715_9_A03, HEPD0715_9_A04, HEPD0715_9_B03, HEPD0715_9_C01, HEPD0715_9_C03, HEPD0715_9_D02, HEPD0715_9_D03, HEPD0715_9_D04, HEPD0715_9_E01, HEPD0715_9_E02, HEPD0715_9_E03, HEPD0715_9_F01, HEPD0715_9_F02, HEPD0715_9_F03, HEPD0715_9_F04, HEPD0715_9_G01, HEPD0715_9_H01, HEPD0715_9_H04
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 24585404 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 24586197. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Abca3 Mutation:  92 strains or lines available
References
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory