Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hic1tm2.1Kori
Name:	hypermethylated in cancer 1; targeted mutation 2.1, Vladimir Korinek
MGI ID:	MGI:4946620
Synonyms:	Hic1cit
Gene:	Hic1  Location: Chr11:75055391-75060345 bp, - strand  Genetic Position: Chr11, 45.76 cM
Alliance:	Hic1tm2.1Kori page

Germline Transmission:	Earliest citation of germline transmission: J:170337
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked flpe-neo cassette was inserted upstream of exon 2. Most of exon 2 was replaced with a citrine gene. Flp-mediated recombination removed the flpe-neo cassette. (J:170337)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

67 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hic1 Mutation:	36 strains or lines available

Original:	J:170337 Pospichalova V, et al., Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Genesis. 2011 Mar;49(3):142-51
All:	4 reference(s)