Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mitftm1a(KOMP)Mbp
Name:	melanogenesis associated transcription factor; targeted mutation 1a, Mouse Biology Program, UC Davis
MGI ID:	MGI:4944291
Gene:	Mitf  Location: Chr6:97784013-97998310 bp, + strand  Genetic Position: Chr6, 45.05 cM
IMPC:	Mitf gene page

Mutant Cell Lines:	DEPD0007_3_A11, DEPD0007_3_B07, DEPD0007_3_C09, DEPD0007_3_D12, DEPD0007_3_E07, DEPD0007_3_E08, DEPD0007_3_E10, DEPD0007_3_F07, DEPD0007_3_F10, DEPD0007_3_F11, DEPD0007_3_G11, DEPD0007_3_H08, DEPD0007_3_H09, DEPD0007_3_H12
Germline Transmission:	Unknown
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 97980364 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 97981210. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Mitf Mutation:	72 strains or lines available

Original:	J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:	1 reference(s)