Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pink1tm1Hbu
Name:	PTEN induced putative kinase 1; targeted mutation 1, Hansruedi Bueler
MGI ID:	MGI:4941901
Gene:	Pink1  Location: Chr4:138040720-138053618 bp, - strand  Genetic Position: Chr4, 70.14 cM
Alliance:	Pink1tm1Hbu page

Germline Transmission:	Earliest citation of germline transmission: J:169471
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neo cassette with a 3' loxP site replaced exons 4 and 5. The absence of transcript expression was confirmed by RT-PCR. (J:169471)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pink1 Mutation:	42 strains or lines available

Original:	J:169471 Akundi RS, et al., Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One. 2011;6(1):e16038
All:	10 reference(s)