Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Il17atm1.1(icre)Stck
Name:	interleukin 17A; targeted mutation 1.1, Brigitta Stockinger
MGI ID:	MGI:4940851
Synonyms:	Il17aCre
Gene:	Il17a  Location: Chr1:20801129-20804720 bp, + strand  Genetic Position: Chr1, 6.45 cM, cytoband A
Alliance:	Il17atm1.1(icre)Stck page

Germline Transmission:	Earliest citation of germline transmission: J:169305
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Nucleotide substitutions   Il17atm1.1(icre)Stck expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Il17a (MGI:107364)   Mutation details: A codon-improved cre recombinase gene, preceded by a 5-codon linker sequence and followed by an SV40 intron and poly(A) signal sequences, was inserted immediately after the endogenous start codon in exon 1. Point mutations were introduced into exon 2 of the Il17a gene to disable an internal ATG-site. The neomycin resistance gene cassette that was inserted downstrea of the cre gene was excised by FLPe-mediated recombination to generate the the final allele. (J:169305)

Activity:	Tissue activity of this recombinase allele
Driver:	Il17a (mouse) Summary of all recombinase alleles driven by Il17a. Alliance mouse Il17a gene page

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il17a Mutation:	22 strains or lines available

Original:	J:169305 Hirota K, et al., Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol. 2011 Mar;12(3):255-63
All:	68 reference(s)