Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Ren1tm1.1Sig
Name:	renin 1 structural; targeted mutation 1.1, Curt Sigmund
MGI ID:	MGI:4939805
Synonyms:	sRENflox
Gene:	Ren1  Location: Chr1:133278412-133288058 bp, + strand  Genetic Position: Chr1, 57.91 cM
Alliance:	Ren1tm1.1Sig page

Germline Transmission:	Earliest citation of germline transmission: J:169129
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	C57BL/6J-Tyrc-2J

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 1a (Ia). An additional loxP site was inserted downstream of exon 1a (Ia). Flp-mediated recombination removed the neo cassette leaving exon 1a (Ia) floxed. (J:169129)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:	36 strains or lines available

Original:	J:169129 Xu D, et al., Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7
All:	4 reference(s)