Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mecp2tm3.1Bird
Name:	methyl CpG binding protein 2; targeted mutation 3.1, Adrian Bird
MGI ID:	MGI:4938309
Synonyms:	MECP2-EGFP
Gene:	Mecp2  Location: ChrX:73070198-73129296 bp, - strand  Genetic Position: ChrX, 37.63 cM
Alliance:	Mecp2tm3.1Bird page

Germline Transmission:	Earliest citation of germline transmission: J:168822
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Reporter) Mutation:    Insertion   Mutation details: A targeting construct was designed to insert an enhanced green fluorescent protein sequence (EGFP) sequence (preceded by sequence for linker peptide CKDPPVAT) and a loxP-flanked neomycin (neo) resistance sequence-STOP cassette in the 3' UTR. Subsequent cre-mediated recombination removed the floxed neo-STOP cassette. This allele expresses a chimeric protein with the EGFP peptide linked to the C-terminus of the endogenous peptide. (J:168822)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:	38 strains or lines available

Original:	J:168822 Bird A, Direct Data Submission 2011/02/25. MGI Direct Data Submission. 2011;
All:	12 reference(s)