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Cebpatm1Gonz
Targeted Allele Detail
Summary
Symbol: Cebpatm1Gonz
Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Frank Gonzalez
MGI ID: MGI:2177133
Synonyms: C/EBPalphaf, c/ebpalphafl
Gene: Cebpa  Location: Chr7:34818718-34821353 bp, + strand  Genetic Position: Chr7, 21.02 cM
Alliance: Cebpatm1Gonz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42995
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted 40 bp downstream of the translation start site of the gene and a loxP-flanked neomycin cassette was inserted 1.8 kb downstream of the gene. (J:42995)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cebpatm1Gonz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cebpa Mutation:  16 strains or lines available
References
Original:  J:42995 Lee YH, et al., Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol. 1997 Oct;17(10):6014-22
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory