Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1.1(Otx2)Daac
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Dario Acampora
MGI ID:	MGI:4887449
Synonyms:	R26Otx2
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1.1(Otx2)Daac page

Germline Transmission:	Earliest citation of germline transmission: J:166896
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1.1(Otx2)Daac expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Otx2 (MGI:97451)   Mutation details: A vector containing a floxed neo/STOP cassette followed by the mouse cDNA and an IRES-GFP. Cre-mediated recombination removed the neo/STOP cassette. (J:166896)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:166896 Di Salvio M, et al., Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat Neurosci. 2010 Dec;13(12):1481-8
All:	2 reference(s)