Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rbpjtm1Rsch
Name:	recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Roland Schmid
MGI ID:	MGI:3809241
Synonyms:	Rbpjf
Gene:	Rbpj  Location: Chr5:53713121-53814787 bp, + strand  Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
Alliance:	Rbpjtm1Rsch page

Germline Transmission:	Earliest citation of germline transmission: J:139250
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 6 and a floxed neo cassette was inserted downstream of exon 7. The neo cassette was removed by cre mediated recombination following transient expression of cre in ES cells. Exon 6 and 7 encode the DNA-binding domain. (J:139250)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbpj Mutation:	193 strains or lines available

Original:	J:139250 Nakhai H, et al., Conditional ablation of Notch signaling in pancreatic development. Development. 2008 Aug;135(16):2757-65
All:	6 reference(s)