Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lepm1Yst
Name:	leptin; mutation 1, Yau-Sheng Tsai
MGI ID:	MGI:4880027
Synonyms:	Leptin145E
Gene:	Lep  Location: Chr6:29060220-29073875 bp, + strand  Genetic Position: Chr6, 12.3 cM
Alliance:	Lepm1Yst page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU mutatgenesis induced a T to A transversion in exon 3 that results in the amino acid substitution of glutamic acid for valine at position 145 (V145E). (J:167736)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lep Mutation:	19 strains or lines available

Original:	J:167736 Hong CJ, et al., ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. PLoS One. 2010;5(12):e15333
All:	1 reference(s)