Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pld2tm1.1Gdp
Name:	phospholipase D2; targeted mutation 1.1, Gilbert Di Paolo
MGI ID:	MGI:4880012
Gene:	Pld2  Location: Chr11:70430890-70448936 bp, + strand  Genetic Position: Chr11, 42.99 cM
Alliance:	Pld2tm1.1Gdp page

Germline Transmission:	Earliest citation of germline transmission: J:166741
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6 x 129/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 13, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 15. This allele is created by using either Cre-mediated recombination to remove exons 13-15 and the selection cassette or Flp-mediated recombination to remove the FRT-flanked neo cassette, followed by Cre-mediated recombination to remove exons 13 to 15. The reduction in protein expression was confirmed by western blot analysis. (J:166741)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pld2 Mutation:	48 strains or lines available

Original:	J:166741 Oliveira TG, et al., Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci. 2010 Dec 8;30(49):16419-28
All:	17 reference(s)