Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Rptortm1.1Dmsa
Name:	regulatory associated protein of MTOR, complex 1; targeted mutation 1.1, David M Sabatini
MGI ID:	MGI:4879103
Synonyms:	RaploxP, Raptorf
Gene:	Rptor  Location: Chr11:119493731-119790402 bp, + strand  Genetic Position: Chr11, 83.96 cM, cytoband E2
Alliance:	Rptortm1.1Dmsa page

Germline Transmission:	Earliest citation of germline transmission: J:167208
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 6 was flanked by 5' and 3' LoxP sites located 111 bp upstream and 547 bp downstream, respectively, and an FRT flanked neo cassette was inserted via homologous recombination. The neo cassette was removed by flp mediated recombination. (J:167208)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Rptortm1.1Dmsa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rptor Mutation:	115 strains or lines available

Original:	J:167208 Sengupta S, et al., mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature. 2010 Dec 23;468(7327):1100-4
All:	165 reference(s)