Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fli1tm1.1Morl
Name:	Friend leukemia integration 1; targeted mutation 1.1, Francois Morle
MGI ID:	MGI:4878922
Synonyms:	Fli-1delta
Gene:	Fli1  Location: Chr9:32333500-32454157 bp, - strand  Genetic Position: Chr9, 17.74 cM
Alliance:	Fli1tm1.1Morl page

Germline Transmission:	Earliest citation of germline transmission: J:167426
Parent Cell Line:	ENS (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Two loxP sites were inserted flanking the coding sequence of exon 9 which contains the whole ETS DNA binding and C-terminal domains. This was followed by an FRT flanked neomycin resistance cassette. The selection cassette was subsequenty excised by transient flp expression. Exon 9 was then excised in the germline by cre expression. (J:167426)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fli1 Mutation:	26 strains or lines available

Original:	J:167426 Starck J, et al., Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation. Blood. 2010 Dec 2;116(23):4795-805
All:	1 reference(s)