Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Terttm2.1Rdp
Name:	telomerase reverse transcriptase; targeted mutation 2.1, Ronald DePinho
MGI ID:	MGI:4878865
Synonyms:	TERT-ER
Gene:	Tert  Location: Chr13:73775030-73797962 bp, + strand  Genetic Position: Chr13, 40.12 cM
Alliance:	Terttm2.1Rdp page

Germline Transmission:	Earliest citation of germline transmission: J:167227
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: An ERT2 ligand binding domain was inserted upstream and in-frame of exon 1, and a floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette. (J:167227)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tert Mutation:	52 strains or lines available

Original:	J:167227 Jaskelioff M, et al., Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 6;469(7328):102-6
All:	4 reference(s)