Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fmr1tm1.2Cidz
Name:	fragile X messenger ribonucleoprotein 1; targeted mutation 1.2, Chris I de Zeeuw
MGI ID:	MGI:3808885
Synonyms:	Fmr1 KO2
Gene:	Fmr1  Location: ChrX:67722147-67761569 bp, + strand  Genetic Position: ChrX, 34.83 cM
Alliance:	Fmr1tm1.2Cidz page

Germline Transmission:	Earliest citation of germline transmission: J:108008
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A germline null mutation was created by crossing Fmr1 mice, which have the first coding exon floxed, with mice that express cre-recombinase in the germline (Tg(CAG-cre)13Miya). Gene inactivation was confirmed by a lack of protein expression in the brain and testes as determined by immunoblot analysis. (J:108008)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:	28 strains or lines available

Original:	J:108008 Mientjes EJ, et al., The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis. 2006 Mar;21(3):549-55
All:	47 reference(s)