Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tfap2atm1Will
Name:	transcription factor AP-2, alpha; targeted mutation 1, Trevor Williams
MGI ID:	MGI:2176682
Synonyms:	AP-2 -, AP-2alpha-, AP-2alpha-deficient
Gene:	Tfap2a  Location: Chr13:40868778-40891852 bp, - strand  Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
Alliance:	Tfap2atm1Will page

Germline Transmission:	Earliest citation of germline transmission: J:33031
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced a geonomic fragment containing exon 6 and the first three nucleotides of exon 7, deleting sequences encoding the dimerization domain of the protein. (J:33031)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	26 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	43 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfap2a Mutation:	39 strains or lines available

Original:	J:33031 Zhang J, et al., Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature. 1996 May 16;381(6579):238-41
All:	17 reference(s)