Apptm1.1Ldad
Targeted Allele Detail
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Symbol: |
Apptm1.1Ldad |
Name: |
amyloid beta precursor protein; targeted mutation 1.1, Luciano D'Adamio |
MGI ID: |
MGI:4868766 |
Synonyms: |
AppT668A, APP TA |
Gene: |
App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
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Alliance: |
Apptm1.1Ldad page
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Germline Transmission: |
Earliest citation of germline transmission:
J:166989
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 16 was replaced with a floxed neo cassette and a modified exon 16 in which a point mutation (ACC to GCC) results in the amino acid substitution of alanine for threonine at position 668 (T668A). Cre-mediated recombination removed the neo cassette.
(J:166989)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any App Mutation: |
89 strains or lines available
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Original: |
J:166989 Barbagallo AP, et al., Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One. 2010;5(11):e15503 |
All: |
3 reference(s) |
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