Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apptm2.1Ldad
Name:	amyloid beta precursor protein; targeted mutation 2.1, Luciano D'Adamio
MGI ID:	MGI:4868765
Synonyms:	AppY682G, APP YG
Gene:	App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance:	Apptm2.1Ldad page

Germline Transmission:	Earliest citation of germline transmission: J:166989
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 16 was replaced with a floxed neo cassette and a modified exon 16 in which a point mutations (TAT to GGA) results in the amino acid substitution of glycine for tyrosine at position 682 (Y682G). Cre-mediated recombination removed the neo cassette. (J:166989)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:	89 strains or lines available

Original:	J:166989 Barbagallo AP, et al., Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One. 2010;5(11):e15503
All:	4 reference(s)