Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Rassf5tm1Sblee Name: Ras association (RalGDS/AF-6) domain family member 5; targeted mutation 1, Sean Lee MGI ID: MGI:4868223 Synonyms: Noer1- Gene: Rassf5  Location: Chr1:131104147-131172915 bp, - strand  Genetic Position: Chr1, 56.91 cM Alliance: Rassf5tm1Sblee page

Rassf5tm1Sblee/Rassf5tm1Sblee mice are resistant to TNF-alpha-induced apoptosis Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:166871
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exons 3, 4, and 5 were replaced with a floxed neomycin resistance cassette. (J:166871)

Generation of the Rassf5tm1Sblee allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rassf5 Mutation:	26 strains or lines available

Original:	J:166871 Park J, et al., Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem. 2010 Nov 5;285(45):35029-38
All:	3 reference(s)