Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm8.2Sia
Name:	orthodenticle homeobox 2; targeted mutation 8.2, Shinichi Aizawa
MGI ID:	MGI:4867634
Synonyms:	Otx2deltaFM1deltaFM2
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm8.2Sia page

Germline Transmission:	Earliest citation of germline transmission: J:166617
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Mutation details: The FM1 enhancer was replaced with a floxed neo cassette while the FM2 enhancer was replaced with an FRT-flanked puro cassette. Flp- and cre-mediated recombination remove the selection cassettes leaving a single loxP site in place of FM1 and a single FRT site in place of FM2. (J:166617)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:166617 Sakurai Y, et al., Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol. 2010 Nov 15;347(2):392-403
All:	1 reference(s)