Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nlgn3tm1.1Htz
Name:	neuroligin 3; targeted mutation 1.1, Nathaniel Heintz
MGI ID:	MGI:4867464
Gene:	Nlgn3  Location: ChrX:100342785-100364956 bp, + strand  Genetic Position: ChrX, 43.95 cM
Alliance:	Nlgn3tm1.1Htz page

Germline Transmission:	Earliest citation of germline transmission: J:167116
Parent Cell Line:	C2J (ES Cell)
Strain of Origin:	B6(Cg)-Tyrc-2J/J

Allele Type:    Targeted Mutation:    Nucleotide substitutions   Mutation details: The nucleotide sequence CGT in exon 6 which encodes Arginine at amino acid position 451 was modified to TGC which encodes Cysteine. A floxed neomycin cassette was also inserted in intron 6. The selection cassette was subsequently excised by crossing to Tg(EIIa-cre)C5379Lmgd mice. (J:167116)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlgn3 Mutation:	35 strains or lines available

Original:	J:167116 Chadman KK, et al., Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice. Autism Res. 2008 Jun;1(3):147-58
All:	2 reference(s)