Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grik1tm1Sfh
Name:	glutamate receptor, ionotropic, kainate 1; targeted mutation 1, Stephen F Heinemann
MGI ID:	MGI:2176347
Synonyms:	GLUK5-, GluR5-, GluR5 KO
Gene:	Grik1  Location: Chr16:87692788-88087153 bp, - strand  Genetic Position: Chr16, 50.23 cM
Alliance:	Grik1tm1Sfh page

Germline Transmission:	Earliest citation of germline transmission: J:66021
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 345 bp genomic fragment that contains sequences encoding the membrane I domain required for protein function. Physiological assays on dorsal root ganglion cells of homozygous mice confirmed that no functional receptor was made from this allele. (J:66021)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik1 Mutation:	51 strains or lines available

Original:	J:66021 Mulle C, et al., Subunit composition of kainate receptors in hippocampal interneurons. Neuron. 2000 Nov;28(2):475-84
All:	34 reference(s)