Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Pik3cbtm1Jjz
Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1, Jean Zhao
MGI ID:	MGI:3805847
Synonyms:	p110betaflox
Gene:	Pik3cb  Location: Chr9:98920455-99022264 bp, - strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Alliance:	Pik3cbtm1Jjz page

Germline Transmission:	Earliest citation of germline transmission: J:138565
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:138565)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Pik3cbtm1Jjz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3cb Mutation:	151 strains or lines available

Original:	J:138565 Jia S, et al., Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 2008 Aug 7;454(7205):776-9
All:	15 reference(s)