Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Col1a2tm1Mcbr
Name:	collagen, type I, alpha 2; targeted mutation 1, Daniel McBride
MGI ID:	MGI:3805459
Gene:	Col1a2  Location: Chr6:4505618-4541543 bp, + strand  Genetic Position: Chr6, 1.81 cM
Alliance:	Col1a2tm1Mcbr page

Germline Transmission:	Earliest citation of germline transmission: J:178743
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/SvEv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted upstream of exon 35 and a G to T mutation was inserted in exon 35 resulting in a glycine to cysteine mutation at codon 706. (J:178743)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a2 Mutation:	119 strains or lines available

Original:	J:178743 Daley E, et al., Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model. J Bone Miner Res. 2010 Feb;25(2):247-61
All:	6 reference(s)