Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Prss12tm1.1Peso
Name:	serine protease 12 neurotrypsin (motopsin); targeted mutation 1.1, Peter Sonderegger
MGI ID:	MGI:3804290
Synonyms:	NT-KO
Gene:	Prss12  Location: Chr3:123240562-123300246 bp, + strand  Genetic Position: Chr3, 54.58 cM, cytoband G3
Alliance:	Prss12tm1.1Peso page

Germline Transmission:	Earliest citation of germline transmission: J:137885
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre-mediated recombination was used to remove exon 10 resulting in deletion of the proteolytic domain. (J:137885)

In Mice Carrying this Mutation:

9 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prss12 Mutation:	36 strains or lines available

Original:	J:137885 Reif R, et al., Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J. 2007 Nov;21(13):3468-78
All:	7 reference(s)