Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fli1tm1.1Dkw
Name:	Friend leukemia integration 1; targeted mutation 1.1, Dennis K Watson
MGI ID:	MGI:3803949
Synonyms:	Fli-1deltaCTA
Gene:	Fli1  Location: Chr9:32333500-32454157 bp, - strand  Genetic Position: Chr9, 17.74 cM
Alliance:	Fli1tm1.1Dkw page

Germline Transmission:	Earliest citation of germline transmission: J:137876
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted into exon 9 via homologous recombination resulting in a premature stop codon between the DNA-binding domain and the CTA domain. The neo cassette was removed by germ line, cre-mediated recombination. Removal of the C-terminal domain results in a 40% to 50% reduction in transcriptional activation activity and the production of a truncated protein. (J:137876)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fli1 Mutation:	26 strains or lines available

Original:	J:137876 Zhang XK, et al., The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. 2008 Aug 1;181(3):1644-54
All:	6 reference(s)