Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itgb4tm1Mfel
Name:	integrin beta 4; targeted mutation 1, Maria Laura Feltri
MGI ID:	MGI:3803792
Synonyms:	beta4F
Gene:	Itgb4  Location: Chr11:115865556-115899238 bp, + strand  Genetic Position: Chr11, 80.91 cM
Alliance:	Itgb4tm1Mfel page

Germline Transmission:	Earliest citation of germline transmission: J:137852
Parent Cell Line:	TBV2 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:137852)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb4 Mutation:	107 strains or lines available

Original:	J:137852 Nodari A, et al., Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008 Jun 25;28(26):6714-9
All:	6 reference(s)