Lmnatm7Lgf
Targeted Allele Detail
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| Symbol: |
Lmnatm7Lgf |
| Name: |
lamin A; targeted mutation 7, Loren G Fong |
| MGI ID: |
MGI:4840061 |
| Synonyms: |
LmnaLAO |
| Gene: |
Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
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| Alliance: |
Lmnatm7Lgf page
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Misshapen cell nuclei in embryonic Lmnatm7Lgf/Lmnatm7Lgf fibroblasts
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:165928
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 10, 11, and 12 (and the introns between) were replaced with the corresponding cDNA without the last 30 nucleotides of exon 11 and the first 24 nucleotides of exon 12 to bring the last codon of mature lamin A adjacent to the prelamin A stop codon. This allele is predicted to produce only the mature lamin A isoform.
(J:165928)
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Generation of the Lmnatm7Lgf allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Lmna Mutation: |
82 strains or lines available
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| Original: |
J:165928 Coffinier C, et al., Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010 Jul 2;285(27):20818-26 |
| All: |
3 reference(s) |
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Analysis Tools
