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Targeted Allele Detail
Symbol: Hand1tm1.1(EGFP/cre)Abfi
Name: heart and neural crest derivatives expressed 1; targeted mutation 1.1, Anthony B Firulli
MGI ID: MGI:4838016
Synonyms: Hand1EGFPCredeltaNeo
Gene: Hand1  Location: Chr11:57719539-57722973 bp, - strand  Genetic Position: Chr11, 35.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:165398
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector containing a 3.4 kb EGFP/cre cassette with a 3' Frt-flanked neomycin cassette was introduced into the 5' untranslated region of Hand1. Homologous recombination resulted in deletion of the first exon of Hand1, producing a null allele, and insertion of the EGFP/cre gene under control of the endogenous promoter. Following germline transmission, the neo cassette was deleted by crossing mice to FLPeR homozygous mice. (J:165398)
 Tissue activity of this recombinase allele
Driver: Hand1     Summary of all recombinase alleles driven by Hand1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:  11 strains or lines available
Original:  J:165398 Barnes RM, et al., Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn. 2010 Nov;239(11):3086-97
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory