Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chd7tm1.2Dmm
Name:	chromodomain helicase DNA binding protein 7; targeted mutation 1.2, Donna M Martin
MGI ID:	MGI:4835268
Synonyms:	Chd7-
Gene:	Chd7  Location: Chr4:8690406-8867659 bp, + strand  Genetic Position: Chr4, 3.68 cM
Alliance:	Chd7tm1.2Dmm page

Germline Transmission:	Earliest citation of germline transmission: J:164582
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted up stream of exon 2 and an FRT flanked neo/kan cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed the neo/kan cassette and exon 2. Immunofluorescence analysis confirmed the absence of expression at E10.5 in homozygous embryos. (J:164582)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chd7 Mutation:	136 strains or lines available

Original:	J:164582 Hurd EA, et al., The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 2010 Sep;137(18):3139-50
All:	1 reference(s)